Akademik Veri Yönetim Sistemi
CURRENT IMMUNOTHERAPY LANDSCAPE FOR SOLID TUMORS, ss.1-4, 2024 (SCI-Expanded)
Effective immune response against cancer is a complex approach. Both adaptive and innate immune systems play a role in this process. CD8+ and CD4+ lymphocytes make an "immune synapse" and distinguish whether an antigen is specific to the body or not. While the immune system recognizes cells that have lost their normal structure, prevents their growth and destroys them before they multiply and form cancer, tumor cells have the ability to escape the immune system and even neutralize the host immune response. Treatments are developed based on immune system activity by examining the effects of cytokines, immune checkpoint inhibition, co-stimulatory receptors agonism, manipulation of T cells, oncolytic viruses, vaccines, and other cells in the tumor microenvironment on the tumor.