First trimester maternal serum marker in intrahepatic cholestasis of pregnancy
Clinical and Experimental Obstetrics and Gynecology, cilt.44, sa.4, ss.595-598, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 44 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.12891/ceog3597.2017
- Dergi Adı: Clinical and Experimental Obstetrics and Gynecology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.595-598
- Anahtar Kelimeler: Bile acids, Free β-hCG, Intrahepatic cholestasis of pregnancy, Pregnancy associated plasma protein A
- Trakya Üniversitesi Adresli: Hayır
Özet
Purpose of investigation: The authors investigated the difference between the first-trimester maternal serum markers of intrahepatic cholestasis of pregnancy (ICP) cases and uneventful pregnancies, which might be useful in disease prediction. Materials and Methods: Twenty patients who had ICP and 40 pregnant women as control group were enrolled and the first-trimester maternal serum markers, maternal and fetal outcomes were compared between two groups. First trimester maternal serum markers: pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (β-hCG) are the essential components of aneuploidy screening and prediction of adverse obstetric outcome. Results: Serum PAPP-A and free β-hCG levels were significantly higher in the ICP group. The mean serum PAPP-A was significantly higher in the ICP than control groups (2.4 ± 0.9 MoM vs. 1.2 ± 0.3 MoM: p < 0.001, respectively) and the mean of serum free β-hCG was significantly higher in the ICP than control groups (1.8 ± 1.5 MoM vs. 1.2 ± 0.6 MoM; p = 0.036, respectively). Gestational week at birth and the birth weights were lower in the ICP group (p < 0.001 and p = 0.005, respectively). Conclusion: The first-trimester maternal serum markers were elevated in case of ICP and this might be useful in disease prediction.