Synthesis, structural aspects, and antimicrobial activity investigation of novel macrocyclic amide-containing compounds

Aghatabay N., Gündüz S., Baş A., TÜRKYILMAZ M., KARABULUT H., Dülger B.

Chemistry of Heterocyclic Compounds, cilt.48, sa.6, ss.936-942, 2012 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10593-012-1080-5
  • Dergi Adı: Chemistry of Heterocyclic Compounds
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.936-942
  • Anahtar Kelimeler: Antibiotic, FT-Raman, Macrocycle, Phane system, Physicochemical, Yeast
  • Trakya Üniversitesi Adresli: Evet

Özet

Macrocyclic 16,76-dimethyl-1,7(2,4)-ditriazina-2,6,8, 12-tetraaza-3,5,9,11-tetraoxocyclododecaphane, 16,8 6-dimethyl-1,8(2,4)-ditriazina-2,7,9,14-tetraaza-3,6,10, 13-tetraoxocyclotetradecaphane, 16,96-dimethyl-1,9(2,4)- ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxocyclohexadecaphane, and 1 6,106-dimethyl-1,10(2,4)-ditriazina-2,9,11,18-tetraaza-3, 8,12,17-tetraoxocyclooctadecaphane are synthesized. The compounds are characterized by elemental analyses, Raman, IR, 1H, 13C NMR and mass spectral data. The antimicrobial activities of the compounds are evaluated against several bacteria and yeast cultures and the results were compared with those of commercial antibiotic and antifungal agents. Structure-activity relationships are also discussed. © 2012 Springer Science+Business Media New York.