Gamma radiation synthesis of pH-sensitive CS/PVP/AMPS/AgNO3 grafted cotton gauze for biomedical applications
Radiation Physics and Chemistry, cilt.238, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 238
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.radphyschem.2025.113156
- Dergi Adı: Radiation Physics and Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC
- Anahtar Kelimeler: Chitosan hydrogel, Kinetic models, Methylene blue, pH-sensitive, Wound dressing
- Trakya Üniversitesi Adresli: Evet
Özet
In this study, a new pH-sensitive chitosan (CS)/Polyvinyl Pyrrolidone (PVP)/2-acrylamido-2-methylpropanesulfonic acid (AMPS)/AgNO3 grafted gauze was produced using gamma radiation polymerization. The swelling, swelling kinetics, and pH-sensitivity properties of the prepared CS/PVP/AMPS/AgNp-g-gauze were tested. The model drug preferred in this study was Methylene Blue (MB). FT-IR and SEM analysis have confirmed that CS/PVP/AMPS hydrogel composite-g-gauze was successfully synthesized. It was found that there was an increase in the grafting percentage with increasing AMPS monomer concentration in the formulation. Adding different concentrations of AgNO3 to the reaction medium caused no drastic change in the grafting percentage. Swelling kinetics from the new hydrogel composite-g-gauze was best fitted to both Peppas model and the second-order kinetic equation. Swelling, pH-sensitivity, and swelling kinetics of the hydrogel composite-g-gauze were improved with the addition of CS, PVP, and AMPS in the gel formulation.