Synthesis of some new 3(2H)-pyridazinone derivatives and evaluation of their analgesic-anti-inflammatory and antimicrobial activities

Sukuroglu M., Yamali C., Tiryaki D., KAYNAK ONURDAĞ F., AKKOL E., DOĞRUER D. S.

Letters in Drug Design and Discovery, cilt.10, sa.6, ss.507-514, 2013 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2174/1570180811310060006
  • Dergi Adı: Letters in Drug Design and Discovery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.507-514
  • Anahtar Kelimeler: 3(2H)-Pyridazinone, Acetohydrazide, Analgesic activity, Anti-inflammatory activity, Antibacterial activity, Antifungal activity
  • Trakya Üniversitesi Adresli: Evet

Özet

In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. © 2013 Bentham Science Publishers.