Akademik Veri Yönetim Sistemi
İstanbul Kuzey Klinikleri, cilt.12, sa.3, ss.321-326, 2025 (ESCI)
OBJECTIVE: Sarcopenia is defined as an age-related loss of muscle quantity as well as quality. Also, it is associated with morbidity and mortality. Multiple myeloma (MM) has a unique aspect with its bone involvement. We aimed to investigate the effect of hema- topoietic stem cell transplantation on sarcopenia in MM patients using both CT and metabolic compartment of F-18 FDG PET/CT. METHODS: Patients with MM who received first-line treatment and were eligible for autologous stem cell transplantation (ASCT) were included. FDG PET images before transplantation and after 120 days of ASCT were recorded. RESULTS: When were grouped as below and above 60 years of age, a decrease in muscle mass after treatment was ob- served in both groups (p<0.001). For patients older than 60 years, age was observed to have a significant effect on muscle mass, independent of the treatment (p=0.001). Regarding metabolic assessment of muscles with PET imaging, the lumbar region was observed to be affected by treatment for both age groups (p<0.001). Metabolic volume measurement of the femoral region did not show such difference related to treatment or age. CONCLUSION: We observed a loss in muscle mass in patients with MM related with treatment. Since PET / CT imaging is routinely used to evaluate disease, it may also be used for the evaluation of muscle as quantity as quality. Awareness of sar- copenia should be increased in patients with MM and caregivers and be supported by physiotherapists to preserve and even to increase muscle mass and strength.