Are short-term meteorological fluctuations associated with acute arterial thromboembolism in a five-year time-stratified case-crossover study
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY, cilt.70, sa.11, ss.1-7, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 70 Sayı: 11
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s00484-026-03373-4
- Dergi Adı: INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
- Derginin Tarandığı İndeksler: Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Earth, Atmospheric, & Aquatic Science Collection (ProQuest), Health Research Premium Collection (ProQuest), Scopus, Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, EMBASE, MEDLINE, Zoological Record
- Sayfa Sayıları: ss.1-7
- Trakya Üniversitesi Adresli: Evet
Özet
Background
Acute limb thromboembolism is a high-morbidity vascular emergency. While traditional risk factors explain baseline susceptibility, they cannot predict exact ischemic attack timing, leading to the hypothesis that short-term meteorological fluctuations act as transient environmental stressors predisposing patients with underlying risk factors to these events.
Methods
After screening 113 patients, a retrospective time-stratified case-crossover analysis included 86 patients undergoing emergent surgical thromboembolectomy (January 2019–October 2025). To adjust for fixed individual confounders, meteorological exposures on index event days were compared with matched control days within the same month and year.
Results
Mean cohort age was 70.1 ± 17.2 years (51.2% male), with 70.9% lower extremity involvement. Ambient temperature was significantly higher on event days than control days (18.4 ± 9.1 °C vs. 17.2 ± 9.4 °C; p = 0.012), whereas atmospheric pressure was lower (1012.8 ± 9.5 hPa vs. 1014.5 ± 8.2 hPa; p = 0.028). Relative humidity showed no significant difference (p = 0.192). In conditional logistic regression, each 1 °C ambient temperature increase was associated with a 12% increase in thromboembolism risk, while each 1 hPa atmospheric pressure decrease was associated with an 8% increased risk.
Conclusion
These findings suggest that acute elevations in temperature and concurrent drops in atmospheric pressure may contribute to a heightened short-term risk of arterial thromboembolic events, rather than acting as direct causal triggers. Understanding these transient environmental associations may provide a crucial foundation for future prospective, multicenter studies.