The effects of intracoronary administration of vitamin E on myocardial ischemia-reperfusion injury during coronary artery surgery

CANBAZ S., Duran E., EGE T., SUNAR H., Cikirikcioglu M., ACIPAYAM M.

Thoracic and Cardiovascular Surgeon, cilt.51, sa.2, ss.57-61, 2003 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1055/s-2003-38983
  • Dergi Adı: Thoracic and Cardiovascular Surgeon
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.57-61
  • Anahtar Kelimeler: Alpha tocopherol, Coronary artery bypass grafting, Ischemia-reperfusion injury, Lactate, Troponin I, Vitamin E
  • Trakya Üniversitesi Adresli: Evet

Özet

Background: Vitamin E has a strong antioxidant capacity, and has been used in several ischemia-reperfusion studies. The aim of this study was to investigate the effects of water-soluble vitamin E (alpha-tocopherol) on myocardial protection during coronary artery surgery. Methods: Water soluble vitamin E (100 mg) in tepid saline (n = 14) or tepid saline alone (n = 16) was administered into the coronary arteries at the end of aortic cross-clamping. Cardiac troponin-I (cTn-I), MB-isoenzyme of creatine kinase (CK-MB), myoglobin, blood gas, and lactate levels in systemic and coronary sinus blood and hemodynamic variables were assessed during and after the operation. Results: Eight hours after reperfusion, cTn-I levels increased to 3.06 ± 1.8 ng/ml and 6.97 ± 3.9 ng/ml in the vitamin E group and control group, respectively (p = 0.01). Coronary sinus lactate concentration was 2.68 ± 0.5 mmol/l in the vitamin E group and 4.01 ± 1.5 mmol/l in the control group 60 minutes after reperfusion (p = 0.027). Conclusions: Administration of vitamin E into the coronary arteries before removal of the aortic cross-clamp can reduce myocardial cell injury and protect the myocardium from ischemia-reperfusion injury.