Immunosupressive phenolic constituents from Hypericum montbretii Spach

DEMİRKIRAN Ö., Ahmad Mesaik M., BEYNEK H., Abbaskhan A., Iqbal Choudhary M.

Records of Natural Products, cilt.7, sa.3, ss.210-219, 2013 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 3
  • Basım Tarihi: 2013
  • Dergi Adı: Records of Natural Products
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.210-219
  • Anahtar Kelimeler: Hypericum monbretii Spach., Il-2 production, Immunomodulating inhibitory activity, Phenolics, Reactive oxygen species, T-cell proliferation
  • Trakya Üniversitesi Adresli: Evet

Özet

The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8″ biapigenin (7), methyl chlorogenate (8), 5-O-pcoumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 μg/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach.