Fontan Circulation Might be Associated with Peripartum Cardiomyopa-thy: A Review of Mechanistic and Clinical Aspects

Yalta K., Yetkin E., TAYLAN G.

Current Cardiology Reviews, vol.17, no.6, 2021 (ESCI, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.2174/1573403x17666210316121842
  • Journal Name: Current Cardiology Reviews
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Keywords: Clinical perspectives, Fontan circulation, Fontan operation, Inflammation-oxidation, Peripartum cardiomyopathy, Potential mechanisms
  • Trakya University Affiliated: Yes

Abstract

Fontan operation has been defined as a palliative surgery connecting systemic venous re-turn and pulmonary circulation in patients with certain forms of complex congenital heart disease (CHD). Fortunately, it has improved overall survival and chance of successful pregnancies among these patients. However, Fontan circulation (FC), as a potential trade-off, might be associated with specific late or post-gestational complications, including peripartum cardiomyopathy (PPCM) largely through its adverse effects on the placenta and inflammation-oxidation stress. Importantly, diagnosis of superimposed PPCM in women with FC might be a diagnostic challenge, requiring a high index of suspicion. Accordingly, the present paper aims to highlight the potential association of FC with PPCM evolution largely based on certain mechanistic and clinical perspectives.