Tyrosinase inhibitory activity of chemical constituents of Euphorbia macrostegia

DEMİRKIRAN Ö., TOPÇU G., Azarpira A., Choudhary M. I.

Chemistry of Natural Compounds, cilt.50, sa.5, ss.810-813, 2014 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s10600-014-1089-3
  • Dergi Adı: Chemistry of Natural Compounds
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.810-813
  • Anahtar Kelimeler: 2-(4-hydroxyphenyl)ethylhentriacontanoate, Euphorbia macrostegia Boiss, flavonoid glycosides, long chain fatty acids, tyrosinase inhibitory activity
  • Trakya Üniversitesi Adresli: Evet

Özet

The chloroform extract of the aerial parts of E. macrostegia has yielded a new compound, 2-(4-hydroxyphenyl)-ethylhentriacontanoate (1), along with hentriacontan-1-ol (2), lupenone (3), cycloart-22-ene-3,25-diol (4), 3,3′,4′-tri-O-methylellagic acid (5), cleomiscosin (6), and glucoclioniasterol (stigmast-5-en-3-O-β-glucopyranoside) (7), and from the ethyl acetate extract of aerial parts of the plant isoquercetin (8), quercetin-3-O-α-arabinofuranoside (avicularin) (9), and rutin (10) have been isolated. Compounds 1-10 were tested for their tyrosinase inhibitory activity, and 2 exhibited an IC50 value of 71.4 μM, almost comparable to standard kojic acid (IC50 58.2 μM). Compounds 1-4 also showed good activity with IC50 values of 77.2, 78.6, 71.4, and 77.5 μM, respectively.