Effects of oral continuous and transdermal cyclic 17-β estradiol and norethindrone acetate replacement therapy on platelet aggregation in postmenopausal women

Kaplan P. B., GÜÇER F., SAYIN N. C., Yüce M. A., YARDIM T.

Journal of Reproductive Medicine for the Obstetrician and Gynecologist, cilt.47, sa.8, ss.651-655, 2002 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 8
  • Basım Tarihi: 2002
  • Dergi Adı: Journal of Reproductive Medicine for the Obstetrician and Gynecologist
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.651-655
  • Anahtar Kelimeler: Platelet aggregation, Postmenopausal hormone replacement therapy, Postmenopause
  • Trakya Üniversitesi Adresli: Evet

Özet

OBJECTIVE: To evaluate the effects of an oral continuous and transdermal cyclic 17-β estradiol and norethindrone acetate combination on platelet aggregation in postmenopausal women. STUDY DESIGN: Fifty postmenopausal women were randomly assigned to receive 17-β estradiol and norethindrone acetate either orally continuously or transdermally cyclically and sequentially. Platelet counts and maximum platelet aggregation rates were measured before and after three months treatment. RESULTS: At three months there were no significant changes in platelet counts or in adenosine diphosphate-induced or epinephrine-induced platelet aggregation rates in either treatment group. CONCLUSION: Hormone replacement treatment with a 17-β estradiol and norethindrone acetate combination either orally continuously or transdermally cyclically and sequentially does not affect platelet aggregation in postmenopausal women.