THE Pd(II) COMPLEX INVOLVING A NEW PYROLE-BASED LIGAND: SYNTHESIS, SPECTRAL ANALYSIS, AND ANTIMICROBIAL ACTIVITY КОМПЛЕКС НА Pd(II) СО НОВ ЛИГАНД НА ОСНОВА НА ПИРОЛ: СИНТЕЗА, СПЕКТРАЛНА АНАЛИЗА И АНТИМИКРОБНА АКТИВНОСТ

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BOZ M., Tetik Ö., ALTUN Ö.

Macedonian Journal of Chemistry and Chemical Engineering, cilt.41, sa.2, ss.251-259, 2022 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.20450/mjcce.2022.2526
  • Dergi Adı: Macedonian Journal of Chemistry and Chemical Engineering
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
  • Sayfa Sayıları: ss.251-259
  • Anahtar Kelimeler: Biological activity, Heterocyclic compounds, Palladium(ii), Spectral characterization
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Trakya Üniversitesi Adresli: Evet

Özet

In the current study, firstly, a new pyrrole-based ligand (3,4-(ethylenedimercaptodiacetoxy)-N-(benzyl)-diethyl-2,5-pyrroledicarboxylate (L) was synthesized in the presence of diethyl-N-benzyl-3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate and 2,2'-(ethane-1,2-diylbis(sulfanediyl))diacetylchloride. Then, the palladium(II) complex of the synthesized ligand was obtained, and its structural features were examined by spectral (HRMS, ESI-MS, UV-Visible, FTIR, 1H NMR, 13C NMR, XRD-POWDER, SEM, EDX) and thermogravimetric (TG-DTA) techniques. The spectral and thermal measurements of the ligand and its Pd(II) complex show that the ligand is coordinated to the Pd2+ ion. Antimicrobial activities of both the ligand and its palladium complex were examined. It was determined that whereas the ligand indicated modest antimicrobial activity against Staphylococcus aureus and Candida albicans at a concen-tration of 6.25 μg/ml, the palladium complex was significantly effective against C. albicans at a concen-tration of 6.25 μg/ml.