THE Pd(II) COMPLEX INVOLVING A NEW PYROLE-BASED LIGAND: SYNTHESIS, SPECTRAL ANALYSIS, AND ANTIMICROBIAL ACTIVITY КОМПЛЕКС НА Pd(II) СО НОВ ЛИГАНД НА ОСНОВА НА ПИРОЛ: СИНТЕЗА, СПЕКТРАЛНА АНАЛИЗА И АНТИМИКРОБНА АКТИВНОСТ
Macedonian Journal of Chemistry and Chemical Engineering, cilt.41, sa.2, ss.251-259, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.20450/mjcce.2022.2526
- Dergi Adı: Macedonian Journal of Chemistry and Chemical Engineering
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
- Sayfa Sayıları: ss.251-259
- Anahtar Kelimeler: Biological activity, Heterocyclic compounds, Palladium(ii), Spectral characterization
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Trakya Üniversitesi Adresli: Evet
Özet
In the current study, firstly, a new pyrrole-based ligand (3,4-(ethylenedimercaptodiacetoxy)-N-(benzyl)-diethyl-2,5-pyrroledicarboxylate (L) was synthesized in the presence of diethyl-N-benzyl-3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate and 2,2'-(ethane-1,2-diylbis(sulfanediyl))diacetylchloride. Then, the palladium(II) complex of the synthesized ligand was obtained, and its structural features were examined by spectral (HRMS, ESI-MS, UV-Visible, FTIR, 1H NMR, 13C NMR, XRD-POWDER, SEM, EDX) and thermogravimetric (TG-DTA) techniques. The spectral and thermal measurements of the ligand and its Pd(II) complex show that the ligand is coordinated to the Pd2+ ion. Antimicrobial activities of both the ligand and its palladium complex were examined. It was determined that whereas the ligand indicated modest antimicrobial activity against Staphylococcus aureus and Candida albicans at a concen-tration of 6.25 μg/ml, the palladium complex was significantly effective against C. albicans at a concen-tration of 6.25 μg/ml.