Cytotoxic effect of Cotinus coggygria extract on Hep3B cancer cell line
Natural Product Research, cilt.37, sa.23, ss.4004-4007, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 23
- Basım Tarihi: 2023
- Doi Numarası: 10.1080/14786419.2022.2158462
- Dergi Adı: Natural Product Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.4004-4007
- Anahtar Kelimeler: AML12, Cotinus coggygria, cytotoxic effect, Hep3B
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Trakya Üniversitesi Adresli: Evet
Özet
Cotinus coggygria Scop. is a medicinal plant which contains a variety of precious phytochemical compounds applicable in traditional medicine. The aim of this study is to investigate the cytotoxic effect of Cotinus coggygria extract on Hep3B cancer cells. The cytotoxic effect was measured by MTT assay. Based on IC50 values, the C. coggygria leaf extract showed cytotoxic effect on Hep3B cancer cells, which was found better at 24 h (IC50 = 3.642) then at 48 h (IC50 = 3.956). Also, the dose of C. coggygria extract showed negative correlation (p < 0.05) with cell viability of 24 h and 48 h and positive correlation (p < 0.05) with cytotoxic effect of 24 h and 48 h. The cytotoxic effects were concentration-time dependent. According to our study, C. coggygria extract had protective effect at 24 h on AML12 cell line and cytotoxic effect on the Hep3B cancer cell line, where it indicates that it may have an antitumorigenic effect.