The relationship between serum myeloperoxidase levels and major cardiovascular events in patients with acute coronary syndrome

Arslan S., Erol M. K., KIZILTUNÇ A., Bozkurt E., Gurlertop H. Y.

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, cilt.33, sa.8, ss.452-459, 2005 (ESCI, Scopus, TRDizin)

Özet

Objectives: This study was planned to assess the relationship between serum myeloperoxidase (MPO) levels and major cardiovascular events in patients with acute coronary syndrome. Study design: Serum MPO levels were measured by ELISA on admission of 243 consecutive patients with acute coronary syndrome (153 acute myocardial infarction, 90 unstable angina). Major cardiac events that occurred during hospitalization and 30-day follow-up period included recurrent angina, reinfarction, ventricular (ventricular tachycardia, ventricular fibrillation) and supraventricular (atrial fibrillation, supraventricular tachycardia) arrhythmias, complete atrioventricular block, clinical heart failure, and death. Correlations were sought between high (n=70, >350 mu g/l) and low (n=173, <= 350 mu g/l) MPO levels and major events. Relative risks were estimated using the Cox proportional hazards regression model. Results: The incidence of hypercholesterolemia was significantly higher in patients with high levels of MPO (p=0.008). A significant association was found between high levels of MPO and increased mortality risk during both hospitalization (hazard ratio-HR, 3.91; 95% CI 1.12-13.6; p=0.03) and 30-day follow-up period (HR 5.08, 95% CI 1.64-15.7; p=0.005). No significant differences were observed between patients with high and low MPO levels with respect to the development of arrhythmia, reinfarction, recurrent angina, and clinical heart failure (p>0.05). Conclusion: The results of this study demonstrate that elevated MPO levels predict death during hospital stay and 30-day follow-up period in patients with acute coronary syndrome.