Akademik Veri Yönetim Sistemi
American Journal of Roentgenology, cilt.192, sa.4, ss.949-955, 2009 (SCI-Expanded, Scopus)
OBJECTIVE. The aim of this study was to investigate dynamic contrast-enhanced MRI(DCE-MRI) for the noninvasive measurement of bladder cancer angiogenesis by correlation with microvessel density, histologic grade, and tumor staging, and to predict the outcome of local recurrence. MATERIALS AND METHODS. Twenty-four patients with bladder cancer were examined using DCE-MRI. Hemodynamic parameters obtained by DCE-MRI included peak time enhancement in the first minute(Emax/1) after contrast administration, second minute(Emax/2)third minute(EEmax/3), fourth minute(EE max/4), and fifth minute(EEmax/5), and the steepest slope. Microvessel density was identified by immunostaining of endothelial cells using FVIII-related antigen. The Mann-Whitney U test, multivariate discriminant analysis, Spearman's correlation coefficient, and analysis of variance were used for statistical analysis. RESULTS. Correlation was seen between DCE-MRI parameters(Emax/1)and steepest slope) and microvessel density(p < 0.05). EEmax/1 and steepest slope were found to have a statistically significant correlation with histologic grade(p < 0.05 and p < 0.01, respectively). A significant difference was seen between groups of patients with and without local recurrence with regard to two of the DCE-MRI parameters(p < 0.05 for Emax/1 and Emax/2). CONCLUSION. The contrast enhancement patterns on DCE-MRI are influenced by tumor angiogenesis, as reflected by elevated microvessel density expression. Therefore, they are valuable indicators for assessing tumor angiogenic activity and tumor neovascularization in bladder cancers. © American Roentgen Ray Society.