The protective effect of moclobemide against hypoxia-induced lethality in mice is not due to a decrease in body temperature
Pharmacology, Biochemistry and Behavior, cilt.51, sa.2-3, ss.245-247, 1995 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 2-3
- Basım Tarihi: 1995
- Doi Numarası: 10.1016/0091-3057(94)00366-q
- Dergi Adı: Pharmacology, Biochemistry and Behavior
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.245-247
- Anahtar Kelimeler: Body temperature, Hypoxia, Moclobemide
- Trakya Üniversitesi Adresli: Evet
Özet
The protective effect of moclobemide, a reversible and highly selective inhibitor of monoamine oxidase-A, against hypoxia-induced lethality was investigated in the present experiment. Moclobemide showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Hypothermia is known to protect animals from hypoxia. Moclobemide also decreased body temperature in mice; however, the hypothermic effect was unrelated to the antihypoxic effect. These results suggest that the protective effect of moclobemide in hypoxia is not due to a decrease in body temperature. © 1995.