Distal sensorimotor polyneuropathy affects skeletal muscle perfusion and metabolism by Tc-99m sestamibi leg scintigraphy in patients with type 2 diabetes

Ugur-Altun B., Durmus-Altun G., ÜSTÜN F., TURGUT N., ALTUN A., Tugrul A.

Endocrinologist, cilt.15, sa.3, ss.146-149, 2005 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1097/01.ten.0000164211.52984.90
  • Dergi Adı: Endocrinologist
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.146-149
  • Anahtar Kelimeler: Leg scintigraphy, Neuropathy, Tc-99m sestamibi, Type 2 diabetes mellitus, Uptake ratio
  • Trakya Üniversitesi Adresli: Evet

Özet

We evaluated the effects of distal symmetric sensorimotor polyneuropathy (DSP) on skeletal muscle perfusion and metabolism in patients with type 2 diabetes. Twenty-three patients with type 2 diabetes underwent electrophysiological and Tc-99m sestamibi leg scintigraphic studies. The study patients were divided into 2 groups: group I (n = 14) with DSP and group II (n = 9) without DSP. We found decreased Tc-99m sestamibi uptake ratios (UR) of both legs in patients with DSP (right UR 7.98 ± 6.85, left UR 7.78 ± 7.01 vs. right UR 8.91 ± 7.98, left UR 8.67 ± 8.23, respectively) than without DSP, although it did not reach statistical significance. The regression equation of right UR was (Tc-99m sestamibi UR = [1.927 X velocity of tibial nerve] - [0.942 X amplitude of sural nerve] - 81.94). In conclusion, electrophysiological variables of tibial motor and sural sensory nerves predict Tc-99m sestamibi UR at leg scintigraphy in patients with type 2 diabetes. Additionally, decreased Tc-99m sestamibi UR in patients with type 2 diabetes with DSP was found. Copyright © 2005 by Lippincott Williams & Wilkins.