Efficacy of granulocyte macrophage colony-stimulating factor on oral mucositis

Kaytan E., Leblebicǐoǧlu B., COŞAR R., Tas Ş., Koyuncu H., ÖNGEN B., ...Daha Fazla

Turk Onkoloji Dergisi, cilt.25, sa.1, ss.20-27, 2010 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2010
  • Dergi Adı: Turk Onkoloji Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.20-27
  • Anahtar Kelimeler: Cytokine, GM-CSF, Mucositis, Radiotherapy, Toxicity
  • Trakya Üniversitesi Adresli: Evet

Özet

OBJECTIVES: Mucositis is a common toxicity in head and neck cancer irradiation, and can cause dose-limiting in patients. There is no widely accepted effective treatment or prevention. The purpose of this study was to investigate the efficacy of granulocyte macrophage colony-stimulating factor (GM-CSF) as a mouthwash to prevent radiation therapy (RT)-induced oral mucositis. METHODS: Thirty-two head and neck cancer patients were enrolled in the study and evaluated prospectively. Lesions were scored using the Radiation Therapy Oncology Group (RTOG) criteria. Variables were age, sex, history of smoking, anatomic region, cancer stage, radiation area, and applied surface area. RESULTS: Grade III-IV mucositis developed in 22 patients (68%) during RT. The only statistically significant relation was between the presence of mucositis and a history of smoking (p=0.04, chi-square). Topical GM-CSF (400 μg 250 cc/day) application had no effect on 1 patient (4%), while 14 patients (64%) showed some improvement and 7 patients (32%) had complete healing. The results of subjective and objective scores were well correlated. GM-CSF had no effect on oral flora, and there was no change in peripheral neutrophil counts. CONCLUSION: Topical use of GM-CSF shows promising effects in controlling RT-induced oral mucositis. © 2010 Association of Oncology.