Brucellosis triggering hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency

PAMUK G. E., Dogan Celik A., UYANIK M. Ş.

Medical Principles and Practice, cilt.18, sa.4, ss.329-331, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1159/000215733
  • Dergi Adı: Medical Principles and Practice
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.329-331
  • Anahtar Kelimeler: Acute hemolytic anemia, Brucellosis, Glucose-6-phosphate dehydrogenase deficiency
  • Trakya Üniversitesi Adresli: Evet

Özet

Objectives: To present a case of acute brucellosis triggering acute hemolytic anemia in a subject with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Clinical Presentation and Intervention: A 17-year-old male patient presented with fever, malaise and jaundice. His blood and bone marrow cultures yielded Brucella species. In addition, he was found to have acute hemolytic anemia due to previously undiagnosed G6PD deficiency. He was started on folic acid supplementation and given a combination of doxycycline and rifampicin for 6 weeks. His response to antibiotic therapy was optimal; the hemolytic anemia resolved. There were no further episodes of hemolysis. Conclusion: This case showed that the differential diagnosis of acute hemolytic anemia in subjects with G6PD deficiency should include brucellosis, especially in regions where the infection is endemic. Copyright © 2009 S. Karger AG, Basel.