Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease
Revista da Associacao Medica Brasileira, vol.68, no.10, pp.1428-1433, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 68 Issue: 10
- Publication Date: 2022
- Doi Number: 10.1590/1806-9282.20220514
- Journal Name: Revista da Associacao Medica Brasileira
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
- Page Numbers: pp.1428-1433
- Keywords: Atherosclerosis, Coronary artery disease, Nonalcoholic fatty liver disease
- Open Archive Collection: AVESIS Open Access Collection
- Trakya University Affiliated: Yes
Abstract
OBJECTIVE: In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis. METHODS: In this cross-sectional study, female patients aged <55 years and male patients aged <50 years were enrolled. Both male and female patients underwent coronary angiography and abdomen ultrasonography between 2014 and 2019. A stepwise binary logistic regression analysis was carried out to evaluate the independent variables related to premature coronary atherosclerosis and nonalcoholic fatty liver disease. A p-value<0.05 was considered statistically significant. RESULTS: nonalcoholic fatty liver disease was present in 44% of patients (n=377). Notably, 62% of the patients were female and the mean age was 44.5 (39-49) years. In a multivariate analysis, nonalcoholic fatty liver disease was shown to be an independent risk factor of premature coronary atherosclerosis (OR 1.438; 95%CI, 1.050-1.969; p=0.024). CONCLUSIONS: The presence of nonalcoholic fatty liver disease is an important independent risk factor for the development of premature coronary atherosclerosis.