Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb

DEMİRKIRAN Ö., Ahmed Mesaik M., BEYNEK H., Abbaskhan A., Iqbal Choudhary M.

Phytochemistry, cilt.70, sa.2, ss.244-249, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.phytochem.2008.10.006
  • Dergi Adı: Phytochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.244-249
  • Anahtar Kelimeler: Benzophenone glycosides, Guttiferae, Hypericum thasium, Inhibition of ROS, Reactive oxygen species (ROS)
  • Trakya Üniversitesi Adresli: Evet

Özet

The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3, 8′′-biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production. © 2008 Elsevier Ltd. All rights reserved.