Systemic antineutrophil cytoplasmic antibody vasculitis in a patient with chronic lymphocytic leukemia. Quite a rare diagnosis

PAMUK G. E., UYANIK M. Ş., Demir M., Tekgündüz E., TURGUT B., SOY M.

Leukemia Research, cilt.31, sa.8, ss.1149-1151, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.leukres.2006.08.017
  • Dergi Adı: Leukemia Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1149-1151
  • Anahtar Kelimeler: ANCA-associated vasculitis, Chronic lymphocytic leukemia, Malignancy, Microscopic polyangiitis
  • Trakya Üniversitesi Adresli: Evet

Özet

There might be rheumatic manifestations of malignant diseases, especially those of the hematological type. Until now, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in chronic lymphocytic leukemia (CLL) has been reported on only very few occasions. Here, we present our patient with Rai stage II CLL who came to us with constitutional symptoms. She turned out to have hematuria with dysmorphic erythrocytes and developed hemoptysis. She had pulmonary-renal syndrome and was diagnosed with p-ANCA positive microscopic polyangiitis. She is currently using prednisolone and cyclophosphamide and undergoing regular hemodialysis. Constitutional symptoms in patients with hematological malignancies should make the physicians consider systemic vasculitis after exclusion of disease-related complications. © 2006 Elsevier Ltd. All rights reserved.