Synthesis, spectral analysis, antimicrobial, cytotoxicity, and antioxidant studies of gold(III) complex of caffeine

ALTUN Ö., Şuözer M.

Journal of Coordination Chemistry, cilt.72, sa.12, ss.2091-2105, 2019 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 12
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/00958972.2019.1629430
  • Dergi Adı: Journal of Coordination Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2091-2105
  • Anahtar Kelimeler: antimicrobial activity, antioxidant activity, cytotoxicity, Gold(III), spectral analysis
  • Trakya Üniversitesi Adresli: Evet

Özet

In the present study, the reactions involving caffeine (CA) and gold(III) were investigated. The synthesized complex was characterized by using mass, UV–visible, FTIR, 1H and 13C NMR, and TG-DTA analyses. From these analyses, it is predicted that the complex has the formula [Au(CA)2(Cl)2]Cl. In addition, antimicrobial, cytotoxicity, and antioxidant activities of the obtained complex were investigated. Investigation of antimicrobial properties demonstrated that the complex has important antibacterial and antifungal activities. The cytotoxic activity of the complex showed potent cytotoxicity against growth of human prostate (Du145), cervix (HeLa), colon (HT29), and breast (MCF7) cancer cells. Additionally, the complex showed significant antioxidant activity.