Akademik Veri Yönetim Sistemi
Yeni Symposium, cilt.44, sa.2, ss.59-63, 2006 (Scopus)
Objective: Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the white matter of central nervous system. Evoked potentials (EP) can be used to show the demyelinated areas and to show multicenter involvement. In this study, brainstem auditory evoked potentials (BAEP) were evaluated in patients with relapsing-remitting MS (RRMS), and the diagnostic value of BAEP was evaluated. Method: Twenty-two patients with RRMS (mean ages 33.7±8.8), and 23 control subjects (mean age 34.6±8.1) were included. Neurological examination, cranial magnetic resonance imaging (MRI), and EP were evaluated for patients. Neurological examination and EP were evaluated for control subjects. Findings: Brainstem involvement was demonstrated in six patients with clinical examination (%27), in 11 patients with MRI (50%), in 12 patients with BAEP (54%). In BAEP, latency of fifth wave, 1-5 and 3-5 interpeak latency were found significantly longer in patients than control subjects (p<0.05). 9 of 16 patients (56%) who had no brainstem involvement with neurological examination, and 4 of 11 patients (36%) who had no brainstem involvement with MRI, had brainstem involvement with BAEP. In 4 patients who had no brainstem involvement with MRI and clinical examination, brainstem involvement was demonstrated with BAEP. Discussion and Conclusion: BAEP may diagnostic have value in patients with RRMS to show subclinical brainstem involvement.