Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X

ALTUN A., YAPRAK M., AKTOZ M., Vardar A., Betul U., ÖZBAY G.

Neuroscience Letters, cilt.327, sa.2, ss.143-145, 2002 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 327 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0304-3940(02)00368-3
  • Dergi Adı: Neuroscience Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.143-145
  • Anahtar Kelimeler: Angina, Nervous system, Normal coronary angiography, Sympathovagal imbalance
  • Trakya Üniversitesi Adresli: Evet

Özet

We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (P=0.04). Peak and Δ melatonin (peak-lowest melatonin) were found lower in patients with cardiac syndrome X (P=0.039 and P=0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients. © 2002 Published by Elsevier Science Ireland Ltd.