Akademik Veri Yönetim Sistemi
MOLECULAR BIOLOGY REPORTS, cilt.53, sa.1, 2026 (SCI-Expanded, Scopus)
Background Matrix Gla Protein (MGP) plays a critical role in vascular calcification and extracellular matrix regulation, processes implicated in cerebrovascular pathology. This study aimed to evaluate the potential association between two MGP gene single nucleotide polymorphisms (SNPs), G-7 A (rs1800801) and T-138 C (rs1800802), and susceptibility to ischemic stroke. Methods and Results A total of 230 individuals, including 115 patients with ischemic stroke and 115 healthy controls, were enrolled. Genomic DNA was extracted, and genotyping was performed using the PCR-RFLP method. Genotype and allele frequencies were statistically compared to assess their association with disease risk. No significant association was observed between the G-7 A polymorphism and ischemic stroke under genotype distribution or genetic models (p = 0.33; allelic model OR: 0.77, 95% CI: 0.52-1.14). In contrast, the T-138 C variant demonstrated statistically significant differences between groups (p = 0.015) and was associated with increased ischemic stroke risk under dominant (OR: 1.89, 95% CI: 1.12-3.19), recessive (OR: 3.54, 95% CI: 1.13-11.12), and allelic models (OR: 1.83, 95% CI: 1.20-2.78), suggesting apossible relationship with stroke susceptibility. Conclusions These findings indicate that the MGP T-138 C polymorphism may contribute to ischemic stroke risk and could serve as a potential biomarker, whereas the G-7 Avariant appears to be unrelated to disease susceptibility. Further large-scale studies are needed to confirm these results. This is the first study to evaluate this association in a Turkish population.