Akademik Veri Yönetim Sistemi
CELL BIOCHEMISTRY AND BIOPHYSICS, cilt.84, sa.1, ss.801-813, 2026 (SCI-Expanded, Scopus)
Breast cancer is one of the most common types of cancer among women worldwide, and the liver is one of the organs most affected by tumor-induced alterations. Proteins, the basic building blocks of a cell membrane, play an important role in cell-to-cell communication and interactions with the extracellular matrix. They also constitute an excellent source for disease detection due to their potential as discovery-phase candidates. In this study, we aimed to examine tumor-burden-induced proteomic alterations in liver tissue in an Ehrlich ascites-induced breast tumor model. In our study, tumor development and its effects on the liver in the experimental model were evaluated in detail using proteomic analyses. As a result of the proteomic analysis, 20 significant proteins were identified in the breast tumor group compared to the control liver tissue. These proteins stand out as molecules that can be evaluated as potential discovery-phase candidates in liver damage. Our study provides an important step towards the discovery of new candidates to better understand the effects of breast tumor induction on the liver and the usability of these candidates in clinical practice.