Gold(I)-Catalyzed Annulation of Pyridines Containing Alkyne: Synthesis of N-Alkenyl Pyridonyl Azides via Rearrangement
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/jhet.70240
- Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, EMBASE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Trakya Üniversitesi Adresli: Evet
Özet
A novel strategy, involving the preparation of gold-catalyzed cyclization salts and the rearrangement of these salts in the presence of azides, has been developed for the synthesis of N-alkenyl pyridonyl azides. The method was proven to tolerate a large number of groups and to produce moderate to excellent yields of transformation in reactions involving chains of different lengths. The usage of powerful electron-withdrawing groups, such as the nitro group, determined the method's limitations. The five-membered ring was shown to be easier to create in the first stage when rings of various sizes were formed with trifluoromethyl groups, whereas the six-membered ring was more reactive in the second stage.