Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats
Brain Research, cilt.943, sa.1, ss.101-104, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 943 Sayı: 1
- Basım Tarihi: 2002
- Doi Numarası: 10.1016/s0006-8993(02)02618-5
- Dergi Adı: Brain Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.101-104
- Anahtar Kelimeler: Allodynia, Magnesium, Morphine, Neuropathic pain
- Trakya Üniversitesi Adresli: Evet
Özet
The response to opioids is reduced in neuropathic pain states. We examined the effect of the combination of morphine (0.1 mg/kg) and magnesium sulfate (125 mg/kg) on behavioral signs of neuropathic pain in spinal nerve ligated rats. Administered alone, neither drug produced any effect, but the combination exerted a significant anti-allodynic effect, which was partially reversed by naloxone. These results suggest that combining low doses of magnesium sulfate with opiates might be an alternative in treating neuropathic pain, with reduced risk of side effects. © 2002 Elsevier Science B.V. All rights reserved.