New synthesis of novel 1,2-dihydrofuro[3,4-d]pyrimidines
Tetrahedron, cilt.73, sa.31, ss.4509-4512, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 31
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.tet.2017.05.072
- Dergi Adı: Tetrahedron
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.4509-4512
- Anahtar Kelimeler: Acyl azide, Curtius rearrangement, Furo[3,4-d]pyrimidine, Pyrimidine, İntramolecular cyclization
- Trakya Üniversitesi Adresli: Evet
Özet
We describe the synthesis of a novel class of compounds, 1,2-dihydrofuro[3,4-d]pyrimidines (15, 16, 18, 20) starting from dimethyl furan-3,4-dicarboxylate 6. Synthesis of these compounds consist of two basic parts: Formation of 4-(2-azido-2-oxoethyl)furan-3-carbonyl azide 11 by eight organic reactions and formation of final products by intramolecular cyclization after two selective Curtius rearrangements of acyl azides 11.