A destroyer immunologic cause in small cell lung carcinoma: Ectopic Cushing's syndrome Küçük hücreli akciǧer kanserinde yıkıcı bir durum: Ektopik Cushing sendromu

ÇİÇİN, İRFAN; Uzunoǧlu, Sernaz; ERMANTAŞ, NİLAY; USTA, UFUK; TEMİZÖZ, OSMAN; KARAGÖL, HAKAN

doi:10.5174/tutfd.2008.00718.1

A destroyer immunologic cause in small cell lung carcinoma: Ectopic Cushing's syndrome Küçük hücreli akciǧer kanserinde yıkıcı bir durum: Ektopik Cushing sendromu

ÇİÇİN İ., Uzunoǧlu S., ERMANTAŞ N., USTA U., TEMİZÖZ O., KARAGÖL H.

Trakya Universitesi Tip Fakultesi Dergisi, cilt.27, sa.3, ss.312-314, 2010 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 27 Sayı: 3
Basım Tarihi: 2010
Doi Numarası: 10.5174/tutfd.2008.00718.1
Dergi Adı: Trakya Universitesi Tip Fakultesi Dergisi
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.312-314
Anahtar Kelimeler: Cushing's syndrome, Immunosuppression, Small cell lung cancer
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Trakya Üniversitesi Adresli: Evet

Özet

Ectopic secretion of adrenocorticotropic hormone (ACTH) related Cushing's syndrome (CS) is more frequently observed than many other paraneoplastic syndromes in patients with small cell lung cancer. Suppression of the cellular immune system in these patients is severe problem for both patients and physicians. In addition, the chemotherapy has been caused to severity and higher rate of hematological toxicity. We present a case of small cell lung cancer having a very poor prognosis, with a compressed humoral and cellular immune system due to an ectopic secretion of ACTH related CS. We report a rare case of combined immunosuppression in a case with small cell lung cancer in this paper. In addition, in the light of this special case and literature, we suggest treatment strategies for small cell lung cancer patients with CS. © Medical Journal of Trakya University. Published by Ekin Medical Publishing. All rights reserved.