The Role of Statins in Preventing Contrast-Induced Acute Kidney Injury: A Narrative Review
Angiology, cilt.66, sa.8, ss.701-707, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 66 Sayı: 8
- Basım Tarihi: 2015
- Doi Numarası: 10.1177/0003319714549556
- Dergi Adı: Angiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.701-707
- Anahtar Kelimeler: acute kidney injury, angiography, contrast media, statins
- Trakya Üniversitesi Adresli: Evet
Özet
The incidence of contrast-induced acute kidney injury (CI-AKI) is rising due to increased use of coronary angiography and percutaneous coronary intervention. Many agents, including statins, have been evaluated in several studies for the prevention of CI-AKI. To date, there have been 14 prospective randomized studies regarding the efficacy of statins on the patient. Most of these studies and 3 recent meta-analyses have concluded that statins should be used for this purpose, even in patients with reduced low-density lipoprotein cholesterol levels. However, there are also conflicting results, most likely due to marked heterogeneity of patient characteristics, dosage and administration patterns of statins, definition of CI-AKI, and different statistical analyses. In conclusion, it is uncertain whether statins should be prescribed to prevent CI-AKI in the absence of other indications.