Effect of Different Dialyzer Membranes on the Oxidative Burst Status of Polymorphonuclear Leukocytes in Hemodialysis Patients
TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, cilt.16, sa.2, ss.63-67, 2007 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 2
- Basım Tarihi: 2007
- Dergi Adı: TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.63-67
- Trakya Üniversitesi Adresli: Hayır
Özet
In the present study, it was aimed to investigate whether there is an abnormality in intracellular antioxidant enzyme activities of polymorphonuclear leukocytes (PMNL) of end stage renal disease patients who had been treated with hemodialysis and different types of dialyzer membranes (cuprophane and polysulphonel affect these enzyme activities. Fifteen end -stage renal disease patients undergoing hemodial. ysis treatment were enrolled into the study and they were dialyzed with polysulphone (P) and cuprophane (C) membranes in two consecutive hemodialysis sessions. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in PMNLs before and after each hemodialysis session were determined. A control group was also consisted of 15 healthy subjects to perform the comparisons. Predialysis PMNL SOD (p=D.285 for P dialysis, p=0.512 for C dialysis) and GSH-Px (p=0.285 for P dialysis, p=0.486 for C dialysis) activities of the patients were not different from those of the controls. Similarly, postdialysis PMNL SOD (p=0.838 for P dialysis, p=0.744 for C dialysis) and GSH-Px (p=0.512 for P dialysis, p=0.870 for C dialysis) activities of the patients did not show difference from the data of the controls. Hemodialysis with both types of the membranes did not cause a statistically significant change in PMNL SOD (p=0.460 for P dialysis, p=0.532 for C dialysis) and GSH-Px (p=0.773 for P dialysis, p=0.570 for C dialysis) activities. In conclusion, there is no difference between end -stage renal disease patients under the hemodialysis treatment and the controls with respect to PMNL oxidative stress status. Furthermore, it also seems that both synthetic (polysulphone) and cellulose (cuprophane) membranes have no effect on SOD and GSH-Px enzyme activities in the PMNLs of the hemodialysis patients.