The adriamycin rat/mouse model and its importance to the embryology Adriyamisin sıçan/fare modeli ve embriyolojide önemi

UZ Y. H., Kizilay G., Akpolat M., TOPÇU TARLADAÇALIŞIR Y., SAPMAZ METİN M.

Duzce Medical Journal, cilt.14, sa.2, ss.51-56, 2012 (Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2012
  • Dergi Adı: Duzce Medical Journal
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.51-56
  • Anahtar Kelimeler: Adriamycin, Mouse, Notochord, Rat, VACTERL
  • Trakya Üniversitesi Adresli: Evet

Özet

Rat and mouse models induced by the teratogenic effect of adriamycin are reliable and easly reproducible methods of studying the embryology and molecular biology of a range of complex congenital anomalies similar to those seen in humans with VACTERL association. The mechanism by which adriamycin produces the congenital anomalies found in the VACTERL association is not yet clear. Studies with these models have focused on mainly abnormal notochord morphology, shedding more light on the important role of this structure in the developing embryo. Morover, defective Shh signaling pathway is another emphasized mechanism. This review aims to discuss adriamycin rat and mouse models and their impact on congenital anomalies similar to those seen in humans with VACTERL association, in the light of current literature data. © 2012 Düzce Medical Journal.