Akademik Veri Yönetim Sistemi
Erciyes Medical Journal, cilt.41, sa.1, ss.85-90, 2019 (TRDizin)
Objective: Hyperparathyroidism (HPT) is a frequent endocrine disorder that progresses with an increase in the parathormone (PTH) synthesis and secretion from the chief cells in one or more glands. The common methods used in the imagingof parathyroid adenomas are the ultrasonography and Tc-99m sestamibi scintigraphy (MIBI) scintigraphy. We aimed toinvestigate the determining characteristics and availability of the MIBI scintigraphy technique in detecting eutopic and ectopiclocalized parathyroid adenomas.Materials and Methods: This is a retrospective study. A total of 59 patients diagnosed with primary HPT between 2002and 2010 using parathyroid scintigraphy with Tc99m MIBI imaging and dual-phase dual-isotope technique, which wasreported as parathyroid adenoma, were enrolled into this study. To determine the radiopharmaceutic retention, an earlyparathyroid-to-thyroid ratio (early PT/T), late parathyroid-to-thyroid ratio (late PT/T), early-to-late ratio (E/L), and the retention index (RI) were calculated.Results: The lesions were divided into two groups: ectopic (n=28) and eutopic (n=37). When biochemical parameters werecompared, there was not any statistically significant difference in the physiological parameters excluding the PTH levels. Wedetermined that the level of PTH is the only biochemical parameter that is directly associated with the positivity of MIBI.Moreover, our findings revealed that the E/L ratio is negatively correlated with Ca+2 and P, while the RI ratio exhibited apositive association with Ca+2 and P in the ectopic group.Conclusion: We concluded that the MIBI is currently the best imaging method to diagnose parathyroid adenomas. Theideal imaging protocol should include a combination of a single photon emission computerized tomography study that is notprolonged over 1 h with an early and late planar (15 min and 2 h, respectively) imaging.