Effects of dexmedetomidine infusion on hemodynamic responses in craniotomies Kraniyotomilerde deksmedetomidin i̇nfüzyonunun hemodinamik yanitlar üzerine etkisi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.34, sa.4, ss.236-240, 2006 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 4
- Basım Tarihi: 2006
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.236-240
- Anahtar Kelimeler: Craniotomy, Dexmedetomidine, Haemodynamic response, Incision, Intubation, Skull pins
- Trakya Üniversitesi Adresli: Evet
Özet
Aim: The effectiveness of dexmedetomidine infusion on preventing hemodynamic response to intubation, skull pins and surgical incision in craniotomies was evaluated. Materials and Methods: Fourty ASA I-II patients undergoing craniotomy because of supratentorial tumors were randomised into: study group (n=20) received 1 μg kg h-1 dexmedetomidine, and control group (n=20) received 0.9% NaCl infusion, 5 min. prior to induction. After intubation was performed at 10th minute, infusion rates were reduced to 50% in both groups. Control group received 1 μg kg-1 fentanyl; dexmedetomidine group received 0.9% NaCl intravenously before skull pins. Same drugs were administered to the both groups for premedication, induction and maintenance. Results: Heart rate, systolic and diastolic arterial pressures reduced at 5th minute of infusion compared to initial values in dexmedetomidine group (p<0.001). Systolic and diastolic arterial pressures reduced after induction in both groups (p<0.001). In control group, the three haemodynamic parameters were higher after intubation compared to before intubation (p<0.001); were higher at 1 (p<0.001) and 5 minutes (p<0.05) after skull pins compared to before intubation; heart rate, systolic and diastolic (p<0.05) arterial pressures were higher after surgical incision compared to before intubation (p<0.001). In dexmedetomidine group, intubation and surgical incision did not cause significant haemodynamic response; systolic (p<0.001) and diastolic (p<0.05) arterial pressures were lower at 5 th minute than 1st minute of skull pins. Six patients in control and no patients in dexmedetomidine group needed fentanyl after surgical incision (p<0.001). Conclusion: Dexmedetomidine infusion started before induction is effective for preventing haemodynamic responses to intubation, skull pins and surgical incision in craniotomies.