The association of gene polymorphisms of the angiotensin-converting enzyme and angiotensin II receptor type 1 with ischemic stroke in Turkish subjects of Trakya Region

SİPAHİ T., Güldiken B., GÜLDİKEN S., ÜSTÜNDAĞ S., TURGUT N., BUDAK M., ...Daha Fazla

Trakya Universitesi Tip Fakultesi Dergisi, cilt.26, sa.1, ss.1-8, 2009 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 1
  • Basım Tarihi: 2009
  • Dergi Adı: Trakya Universitesi Tip Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: ACE I/D gene polymorphism, AT1R (A1166C) gene polymorphism, Ischemic stroke, Renin-angiotensin system
  • Trakya Üniversitesi Adresli: Evet

Özet

Objectives: The aim of this study was to investigate the frequency of ACE insertion/deletion (I/D) and AT1R (A1166C) gene polymorphisms in ischemic stroke patients in Trakya region and the relation between these gene polymorphisms and stroke subtypes and vascular risk factors. Patients and Methods: The study involved 162 patients with ischemic stroke and 146 control subjects. Ischemic stroke patients were divided into large and small vessel disease subgroups according to ORG 10172 in Acute Stroke Treatment TOAST criteria. The ACE I/D polymorphism was investigated using polymerase chain reaction (PCR), and the AT1R (A1166C) polymorphism was identified using PCR and restriction fragment length polymorphism (RFLP) assay. Results: The ACE I/D genotype distribution in patients (DD=34.0%, ID=50.0%, II=16.0%) did not differ from those in controls (DD=34.3%, ID=49.7%, II=16.1%). The AT1R A1166C genotype distribution in patients (AA=58.0%, CA=34.6%, CC=7.4%) did not significantly differ from those in controls (AA=60.1%, CA=35.7%, CC=4.2%). There was also no difference among the stroke subgroups regarding the distribution of ACE I/D and AT1R (A1166C) polymorphisms. Conclusion: Our results show that ACE I/D and AT1R (A1166C) gene polymorphisms were not genetic risk factors for ischemic stroke in subjects in Trakya region. © Medical Journal of Trakya University. Published by Ekin Medical Publishing. All rights reserved.