The prognostic value of atrial and brain natriuretic peptides, troponin I and C-reactive protein in patients with sepsis
Experimental and Clinical Cardiology, cilt.13, sa.4, ss.183-188, 2008 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 4
- Basım Tarihi: 2008
- Dergi Adı: Experimental and Clinical Cardiology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.183-188
- Anahtar Kelimeler: C-reactive protein, Intensive care unit, Natriuretic peptides, Prognosis, Sepsis, Troponin I
- Trakya Üniversitesi Adresli: Evet
Özet
Aim: To investigate the plasma levels of atrial and brain natriuretic peptides (ANP and BNP), cardiac troponin I (cTnI) and C-reactive protein (CRP) as prognostic factors for survival in patients with sepsis. Method: Evaluation of serum levels of ANP, BNP, cTnI and CRP of patients an admission to an intensive care unit, two days later, and on the day of discharge from the intensive care unit or on the day of death. Results: ANP levels were significantly higher in the nonsurviving patients (day 1: 70.00±49.54 pg/mL; day 2: 138.85±143.15 pg/mL; and died/discharged day: 375.70±262.66 pg/mL) than surviving patients (day 1: 23.96±29.93 pg/mL; day 2: 10.06±6.03 pg/ML; died/discharged. day: 6.68±100.98 pg/mL, P<0.001). The BNP levels were significantly higher in the nonsurvivors (day 1: 254.78±308.62 pg/mL; day 2: 383.22±307.19 pg/mL; and died/discharged day: 696.47±340.33 pg/mL), than survivors (day 1: 13.72±12.95 pg/mL; day 2: 7.20±5.85 pg/mL; died/discharged day: 4.51±4.64 pg/mL, P<0.001). The cTnI levels were significantly higher in the nonsurviving patients (day 2: 0.16±0.38 μg/L; died/discharged day: 0.78±2.48 μg/L) than surviving patients (day 2: 0.04±0.07 μg/L; died/discharged day: 0.02±0.01 μg/L, P<0.05). The CRP levels were significantly higher in the nonsurvivors (day 2: 119.3±71.5 mg/L; and died/discharged day: 145.7±74.7 mg/L) than sumavors (day 2: 57.0±29.7 mg/L; died/discharged day: 26.8±24.0 mg/L, P<0,05). There were no significont differences between nonsurvivors and survivors for cTnI and CRP on day 1. Conclusion: With the exception of cTnI and CRP on day 1, all of the parameters were significantly powerful to determine nonsurvivors on all days. Among these variables, BNP was the most powerful diagnostic parameter for the prediction of nonsurvivors on all days. © 2008 Pulsus Group Inc. All rights reserved.