Akademik Veri Yönetim Sistemi
NAMIK KEMAL MEDICAL JOURNAL, cilt.13, sa.4, ss.444-450, 2025 (ESCI, TRDizin)
Multiple primary lung cancers (MPLC) may develop either synchronously or metachronously. While synchronous MPLC involves the simultaneous occurrence of histologically distinct tumors, metachronous MPLC arises over time following the treatment of an initial lung cancer. To highlight the diagnostic and therapeutic challenges, we present a rare case of triple metachronous primary lung cancer, accompanied by a systematic review of case reports and reviews published between 2010 and 2024, focusing on clinical, pathological, and radiological aspects. In the presented case, three distinct histopathological subtypes of primary lung cancer developed over an eight-year period. Genetic analysis revealed TP53 and PTEN mutations, potentially contributing to metachronous tumor development. The literature emphasizes the importance of timely imaging and histological confirmation in distinguishing metachronous tumors from recurrence or metastasis. This case represents one of the rare reports of triple metachronous primary lung cancer in the literature and underscores that the diagnostic process necessitates the integrated use of radiological, histopathological, and molecular methods. High clinical vigilance is essential for identifying MPLC in patients with a previous history of lung cancer, and aggressive surveillance strategies-such as low-dose computed tomography-and a multidisciplinary approach are critical for improving patient outcomes.