5-HT7 receptor activation: A novel target for treatment of opioid-induced hyperalgesia - A hypothesis and mini review

TOPUZ R. D., GÜNDÜZ Ö., ULUGÖL A.

Neurology Psychiatry and Brain Research, cilt.21, sa.3, ss.105-107, 2015 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.npbr.2015.04.001
  • Dergi Adı: Neurology Psychiatry and Brain Research
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.105-107
  • Anahtar Kelimeler: 5-HT7 receptors, Opioid-induced hyperalgesia, Serotonin
  • Trakya Üniversitesi Adresli: Evet

Özet

Opioid-induced hyperalgesia is defined as increased nociceptive sensitivity during opioid exposure, which may contribute to the development of antinociceptive tolerance. Systemic administration of 5-HT7 agonists induces antinociceptive activity via action at spinal and supraspinal sites, and accordingly exerts antihyperalgesic effects in capsaicin challenge, nerve injury and diabetic neuropathy models. Neuropathic pain and opioid-induced hyperalgesia share some pathophysiological properties. In conclusion, we hypothesized that drugs with 5-HT7 receptor activating property may have utility in the pharmacotherapy of opioid-induced hyperalgesia.