5-HT7 receptor activation: A novel target for treatment of opioid-induced hyperalgesia - A hypothesis and mini review
Neurology Psychiatry and Brain Research, cilt.21, sa.3, ss.105-107, 2015 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 21 Sayı: 3
- Basım Tarihi: 2015
- Doi Numarası: 10.1016/j.npbr.2015.04.001
- Dergi Adı: Neurology Psychiatry and Brain Research
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.105-107
- Anahtar Kelimeler: 5-HT7 receptors, Opioid-induced hyperalgesia, Serotonin
- Trakya Üniversitesi Adresli: Evet
Özet
Opioid-induced hyperalgesia is defined as increased nociceptive sensitivity during opioid exposure, which may contribute to the development of antinociceptive tolerance. Systemic administration of 5-HT7 agonists induces antinociceptive activity via action at spinal and supraspinal sites, and accordingly exerts antihyperalgesic effects in capsaicin challenge, nerve injury and diabetic neuropathy models. Neuropathic pain and opioid-induced hyperalgesia share some pathophysiological properties. In conclusion, we hypothesized that drugs with 5-HT7 receptor activating property may have utility in the pharmacotherapy of opioid-induced hyperalgesia.