Akademik Veri Yönetim Sistemi
Chemical Research in Chinese Universities, cilt.39, sa.6, ss.968-975, 2023 (SCI-Expanded, Scopus)
In this study, firstly, 3-bromopropanenitrile(2a), ethyl bromoacetate(2b), and 2-bromoethan-1-amine(2c) were added to 5,6-dimethylbenzimidazole(1) and symmetrically-connected N-heterocyclic carbenes(NHC)[(3a–3c)] were synthesized. Then, the NHC precursor compounds were reacted with PdCl2 and Pd (II)-NHC complexes[(4a—4c)] were obtained. The synthesized NHC precursors(3a–3c) and Pd(II)-NHC complexes(4a—4c) were characterized by different spectroscopic methods. The antibacterial activities of these products were measured against bacteria and fungus with the disc diffusion method. Pd(II)-NHC complexes had higher antibacterial activity than the NHC precursors. The synthesized compounds showed antimicrobial activity with different properties from each other. In vitro biological activities of salts and metal complexes on selected bacteria were determined by the broth dilution method based on Clinical and Laboratory Standards Institute guidelines. 1,3-Bis-(2-hydroxyethyl) imidazolinium bromide and 3-(2-ethoxy-2-oxoethyl)-1-(3-aminopropyl)-1H-imidazole-3-ium bromide had activity against Escherichia coli. [Figure not available: see fulltext.].