Notable chenodeoxycholic acid oligomers-synthesis, characterization, and 7α-OR steric hindrance evaluation

KARABULUT H., Rashdan S. A., Dias J. R.

Tetrahedron, cilt.63, sa.23, ss.5030-5035, 2007 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 23
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.tet.2007.03.129
  • Dergi Adı: Tetrahedron
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5030-5035
  • Trakya Üniversitesi Adresli: Evet

Özet

The steric hindrance of the 7α-OR group in bile acid derivatives is very different from the 12α-OR group. The effect of this difference in steric hindrance on the synthesis of cyclocholates has been evaluated with support from AM1 and MM2 calculations. The 13C NMR parameters for cheneodeoxycholic acid-based cyclocholates have been determined. © 2007 Elsevier Ltd. All rights reserved.