Radiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: Drug uptake and drug delivery systems
14th International Conference on Nanosciences and Nanotechnologies, NN 2017, Thessaloniki, Yunanistan, 4 - 07 Temmuz 2017, cilt.5, ss.15990-15997, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Cilt numarası: 5
- Doi Numarası: 10.1016/j.matpr.2018.05.043
- Basıldığı Şehir: Thessaloniki
- Basıldığı Ülke: Yunanistan
- Sayfa Sayıları: ss.15990-15997
- Anahtar Kelimeler: Chitosan, Drug delivery, Hyaluronic acid, Hydrogels, Hydroxiapatite
- Trakya Üniversitesi Adresli: Evet
Özet
In this work, a new chitosan (CS)/hyaluronic acid (HA)/hydroxyapatite (HAP) hydrogels were synthesized by using gamma rays irradiation technique for oral delivery of drugs. The hydrogelss were characterized using fourier transform infrared spectroscopy (FTIR) and the physicochemical properties of shrimp chitosan was determined with both FTIR and scanning electron microscopy (SEM). The use of the hydrogel samples as a drug delivery system was investigated by an anticancer drug. 5-Fluorouracil (5-FU) was used as a model anticancer drug to investigate the drug uptake and release kinetics of hydrogels. The properties of the hydrogels were evaluated in terms of swelling, drug uptake and release behaviours. The addition of hyaluronic acid and hydroxyapatite in the gel structure improved drug uptake and release capability of the new hydrogels.