Relationship Between an Osteoprotegerin Gene Polymorphism and Diabetic Vascular Complications

SOYSAL ATİLE N., GÜLDİKEN S., SİPAHİ T., YÜKÇÜ F., EKİZ BİLİR B., Huseyin S., ...Daha Fazla

CLINICAL LABORATORY, cilt.61, sa.5-6, ss.595-601, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 5-6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.7754/clin.lab.2014.141126
  • Dergi Adı: CLINICAL LABORATORY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.595-601
  • Anahtar Kelimeler: Complications, Diabetes mellitus, Osteoprotegerin, Polymorphism
  • Trakya Üniversitesi Adresli: Evet

Özet

Background: Osteoprotegerin (OPG), which was recently identified as a vascular marker, is increased in patients with diabetes mellitus (DM). This study evaluated the frequency of the OPG gene single nucleotide A163G polymorphism and its association with diabetic microvascular and macrovascular complications. Methods: The A163G polymorphism of the OPG gene was assessed in the peripheral blood of 116 patients with type 2 DM and 107 healthy subjects by polymerase chain reaction and restriction fragment length polymorphism. Microvascular and macrovascular complications were evaluated in diabetic patients. Results: Statistical analysis showed no significant difference in distribution of the OPG A163G polymorphism in the diabetic and control groups. Similarly, this polymorphism was not associated with microvascular or macrovascular complications. Conclusions: This OPG polymorphism does not play a role in the development of microvascular and macrovascular complications in patients with DM.