Akademik Veri Yönetim Sistemi
UNION OF THRACE UNIVERSITIES VII. INTERNATIONAL HEALTH SCIENCES CONGRESS, Tekirdağ, Türkiye, 21 - 22 Ocak 2025, ss.214, (Özet Bildiri)
Aim: Remote ischaemic postconditioning, involving short, repeated cycles of ischaemia during reperfusion, has shown protective effects in several systems.We aimed to investigate the impact of ischaemic postconditioning on LPS-induced organ dysfunction and its potential transfer via serum.
Methods: After ethical approval, serum samples obtained from the study titled "Effect of ischemic postconditioning on lipopolysaccharide-induced acute lung injury in rats" were used. Forty rats were divided into five groups. Group1(Control) and Group3(RIPostC) rats were administered physiological serum intraperitoneally. Group2(LPS), Group4(LPS+RIPostC), and Group5(LPS+RIPostCserum) rats were administered 10 mg/kg LPS. Group3 and Group4 rats underwent ischemic postconditioning 4 hours after the injection. Group5 rats were administered serum obtained from animals that underwent ischemic postconditioning intravenously. For ischemic conditioning, the rats' legs were subjected to 10 minutes of ischemia, followed by 10 minutes of reperfusion. The levels of AST, ALT, GGT, bilirubin, urea, creatinine, CRP, ceruloplasmin, troponin I and procalcitonin were analyzed in serum samples. The results are presented as mean±standard deviation. One-way analysis of variance(ANOVA) and Tukey test were used for comparisons between groups. Statistical significance was considered at p<0.05.
Results: The bilirubin, GGT, urea, and creatinine levels in Group2 and Group5 were significantly higher compared to Group1 (p<0.05). The bilirubin and creatinine levels in Group4 were also significantly higher compared to Group1 (p<0.05).
Our results suggest that ischaemic postconditioning may protect against LPS-induced liver and kidney injury, but these effects were not mediated by conditioned serum transfusions. Further studies investigating the protective effects of ischaemic postconditioning are needed.
Keywords: ischaemic postconditioning ,lps,organ dysfunction