Prognostic impact of TyG-BRI index on in-hospital mortality in elderly-octogenarian patients with ST-elevation myocardial infarction
POSTGRADUATE MEDICINE, cilt.137, sa.8, ss.830-838, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 137 Sayı: 8
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/00325481.2025.2610842
- Dergi Adı: POSTGRADUATE MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, Educational research abstracts (ERA), EMBASE
- Sayfa Sayıları: ss.830-838
- Trakya Üniversitesi Adresli: Evet
Özet
Objective: The aging population is rapidly growing, increasing the need for practical and accessible risk prediction tools, particularly in elderly patients with ST-elevation myocardial infarction. Traditional risk stratification models often fail to capture the full complexity of cardiovascular risk in this population. The triglyceride (TyG)-glucose index and body roundness index (BRI) have been individually associated with metabolic and cardiovascular risk. This research aimed to assess the prognostic value of the combined TyG-BRI index in predicting in-hospital mortality in octogenarian STEMI patients. Methods: This retrospective observational study included 203 octogenarian STEMI patients (age >= 80 years) admitted to the coronary intensive care unit. The TyG index, BRI, TyG-BRI index, and PNI were calculated using standard formulas. Multivariate logistic regression analysis was performed to detect independent predictors of in-hospital mortality, and ROC curve analysis assessed the discriminative ability of the TyG-BRI index. Results: Among the 203 patients, 56 (27.6%) died during hospitalization. The TyG-BRI index was significantly higher in non-survivors (33.7 vs. 27.17, p < 0.001) and independently predicted in-hospital mortality (OR = 1.32, 95% CI:1.02-1.71, p = 0.031). The optimal TyG-BRI threshold for mortality prediction was >30.7, with a sensitivity of 83% and specificity of 67%. Additionally, low prognostic nutritional index (OR = 0.49, 95% CI:0.30-0.81, p = 0.005) and low glomerular filtration rate (OR = 0.92, 95% CI:0.86-0.99, p = 0.043) were independent predictors of mortality. Conclusion: The TyG-BRI index is a simple, cost-effective, and independent predictor of in-hospital mortality in octogenarian STEMI patients, offering additional prognostic value beyond traditional risk factors. Its ease of calculation using routine laboratory and anthropometric data makes it a practical tool for risk stratification, even in resource-limited settings. Further prospective studies are needed to validate its long-term prognostic value and potential role in personalized treatment strategies for elderly STEMI patients.