Investigation of Antimicrobial and Antitubercular Activities of Some Hydrazone DerivedCompounds

---

Aksöz B. E., Kaynak-Onurdag F., Aksoz E., ÖZGACAR S. Ö.

Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, cilt.24, sa.1, ss.196-200, 2020 (TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 24 Sayı: 1
• Basım Tarihi: 2020
• Doi Numarası: 10.19113/sdufenbed.672554
• Dergi Adı: Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi
• Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.196-200
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Trakya Üniversitesi Adresli: Evet

Özet

Aseriesofhydrazonederivativesweresynthesizedtoinvestigate antifungal,antimicrobialandantitubercularactivities.Theseactivitieswere investigatedagainst Escherichiacoli, Escherichiacoli isolate, Pseudomonas aeruginosa, Pseudomonas aeruginosaisolate (resistant to gentamicin), Staphylococcus aureus, Staphylococcus aureus isolate (MRSA), Enterococcusfaecalis, Enterococcusfaecalis isolate(VRE), Candidaalbicans, Candidakrusei andMycobacteriumtuberculosis. Among the synthesized compounds B23had the best activity against Candida albicanswith 16 μg/mL MIC value and B24had the best activity against Staphylococcus aureus isolate (MRSA) with 16 μg/mL MIC value. The most effective compound against Mycobacteriumtuberculosis is found to be E9 with 32 μg/mL MIC value, achalcone derivative. However, all compounds were determined as ineffective against Escherichia coli and Escherichia coli isolate.