Akademik Veri Yönetim Sistemi
Fertility and Sterility, cilt.76, sa.4, ss.707-711, 2001 (SCI-Expanded, Scopus)
Objective: We evaluated tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) receptor levels in patients with threatened abortion and compared the levels with normal and pathologic pregnancies. Design: A prospective, nonrandomized, case-control study. Setting: Academic research setting. Patient(s): Twenty-two patients with threatened abortion, 18 patients with pathologic pregnancies, 20 healthy pregnant women, and 20 nonpregnant women. Intervention(s): Maternal serum TNF-α and IL-2 receptor levels were measured with a solid-phase, two-site chemiluminescent enzyme immunometric assay method. Main Outcome Measure(s): TNF-α and IL-2 receptor levels. Result(s): The mean ± SEM maternal serum IL-2 receptor level for patients with threatened abortion was 481.3±35.7 U/mL, compared with 426.5±22.4 U/mL in the normal pregnant group. There was no statistically significant difference in the mean ± SEM serum TNF-α level between the patients with threatened abortion and those with normal pregnancies (16.1±2.7 pg/mL vs. 10.9±0.8 pg/mL). The mean ± SEM maternal serum IL-2 receptor level was significantly higher in patients with pathologic pregnancies than in those with normal pregnancies (506.2±27.6 U/mL vs. 426.5±22.4 U/mL). The mean ± SEM maternal serum TNF-α level was significantly higher in patients with pathologic pregnancies than in those with threatened abortion (39.2±9.5 pg/mL vs. 16.1±2.7 pg/mL) and normal pregnancies (39.2±9.5 pg/mL vs. 10.9±0.8 pg/mL). Conclusion(s): In comparison with normal pregnancies, maternal serum IL-2 receptor and TNF-α levels were not significantly increased in patients with threatened abortion with good outcome. © 2001 by American Society for Reproductive Medicine.