Preparation and Characterization of Sodium Alginate Radiation Grafted Poly(N-isopropylacrylamide)/Poly(itaconic acid) Microspheres for Bone Tissue Engineering Applications
ChemistrySelect, cilt.11, sa.10, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 10
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/slct.202506321
- Dergi Adı: ChemistrySelect
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
- Anahtar Kelimeler: alginate, gels, itaconic acid, microspheres, N-isopropylacrylamide, polymerization
- Trakya Üniversitesi Adresli: Evet
Özet
Novel pH- and temperature-responsive semi-interpenetrating network (s-IPN) microspheres were developed via a three-step approach, involving radiation grafting of sodium alginate (SA) onto a poly(N-isopropylacrylamide) (PNIPAAm) /poly(itaconic acid) (PIA) microsphere matrix. In the first step, PNIPAAm microspheres were prepared using the inverse suspension polymerization technique. In the second step, a selected fraction of PNIPAAm microspheres (180–250 µm size range) was used to prepare PNIPAAm/PIA graft copolymers via the radiation-induced modification technique. Subsequently, PNIPAAm/PIA microspheres were immersed in an SA solution, followed by gamma radiation-induced polymerization at a dose of 25 kGy. The prepared s-IPN microspheres were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) analyses. The swelling kinetics of the novel s-IPN microspheres were best described by the Peppas model. The n > 0.5 value in the Peppas model indicates that the mechanism is non-Fickian transport. The swelling behavior, pH-sensitivity, swelling kinetics, and hydrolytic degradation properties of the new s-IPN microspheres were improved by the incorporation of SA and itaconic acid (IA) into the gel structure.